RESEARCH. OUTREACH.

(Excerpt from The Detox Revolution, a book by ACRCF President and Founder Thomas J. Slaga, PhD)

The emphasis of this book on detoxification is to prevent diseases like cancer. But that doesn’t mean we scrap a detoxification strategy if cancer is diagnosed. In fact, once the stage of cancer formation is identified, it is possible, and necessary, to develop a customized intervention strategy with the appropriate protective compounds.

The formulation of essential fats is also very important in cancer prevention. The sulfur compounds from cruciferous vegetables and garlic, the flavonoid compounds from fruits and vegetables, the terpenoids and curcuminoids from spices, chlorophllin from green vegetables, and D-glucarate from fruits and vegetables are particularly potent inhibitors of the tumor initiation stage because they enhance Phase I and Phase II detoxification and DNA repair. In terms of tumor promotion and progression, the antioxidants from fruits and vegetables and critical cellular antioxidants plus essential fats and immune enhancement compounds are very effective because of inhibiting free radicals, inflammation, and cell proliferation, as well as stimulating immune function and cancer cell death.

These compounds are potent inhibitors of the induction of cancer because they stimulate detoxification function. They show promise as agents for the treatment of cancer progression. Many studies have found that they inhibit the proliferation of cancer cells, stimulate apoptosis or cell death, stimulate normal differentiation in cancer cells, counteract the growth of blood vessels to tumors (antiangiogenesis), and/or stimulate the immune system to produce natural killer cells to destroy cancer cells. In some cases, curcumin, silymarin, and omega-3 fatty acids also work synergistically with certain chemotherapeutic agents such as doxorubicin (adriamycin). In addition, curcumin, silymarin (or silibinin), and omega-3 fatty acids also inhibit cox-2, a critical enzyme in cancer cell growth. Certain phytochemicals, notably green tea polyphenols, apigenin, silymarin, and genistein, are effective inhibitors of tyrosine kinases. These and other tyrosine kinase inhibitors are also starting to show promise in cancer treatment because of their ability to counteract cancer cell growth in a very selective manner without many side effects. A combination of these compounds because of their various anticancer mechanisms may be an effective approach to selectively destroying cancer cells.