We have evaluated several inhibitors of the proprotein convertases (PC) such as PDX, CMK and the propeptides of the PCs furin and PACE4. All of these are effective in culture systems. Our ongoing studies using transgenic mice suggest that these inhibitors targeted to the epidermis are able to decrease the carcinogenic effects of UV radiation and chemical skin carcinogens. Read more here.

Andres Klein-Szanto, M.D.
Histopathology Facility
Fox Chase Cancer Center
333 Cottman Ave.
Philadelphia, PA 19111-2497

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